Sibutramine genuine powder

What is it Sibutramine genuine powder 

Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines. Sibutramine is classified as a Schedule IV controlled substance in the United States. In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Sibutramine is a synthetic drug originally developed by Novartis in Switzerland, primarily used for the treatment of obesity. It belongs to a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that can affect neurotransmitter levels in the brain, thereby regulating appetite and energy expenditure. Although there is a significant weight loss effect on some patients in the short term,

Sibutramine genuine powder Its function

is a medication widely used to treat obesity. It reduces appetite and increases satiety by inhibiting the reuptake of neurotransmitters, thereby helping patients lose weight.

developed by Knoll, Inc., Germany, was first launched in the United States in April 1998. As a norepinephrine and 5-HT reuptake inhibitor, sibutramine acts primarily through its metabolites. It can increase physiological satiety, reduce appetite, induce heat production and increase energy consumption by inhibiting the reuptake of monoamine information transmission factors such as 5-HT and norepinephrine, decreased fat accumulation. Obesity Treatment for diet control, exercise failure to reduce and control weight.

p-chlorophenylacetonitrile, KOH and acetonitrile were mixed, and 1,3-= bromopropane was slowly added dropwise at 25 ° C. For reaction. After completion of the reaction, distilled water was added, followed by extraction with hexyl acetate. The extract was washed with water, saturated brine, and dried. The compound was obtained by filtration, concentration under reduced pressure and distillation. Magnesium tablets are dissolved in THF, Dropwise adding isobutyl bromide, then reacting, slowly dropping the THF solution of the compound obtained from the surface, refluxing, and stirring the treated compound with formic acid and formaldehyde solution, the reaction was slowly added to a crushed ice solution of sodium hydroxide with stirring, and then extracted with ether. The extract was washed with saturated brine and water and dried. Filtration and concentration of the filtrate gave sibutramine.

Sibutramine genuine powder Drug use

1.5-HT reuptake inhibitors are used for the treatment of obesity.
2. As an inhibitor of norepinephrine and 5-HT reuptake, sibutramine mainly exerts its effects through its metabolites. It increases physiological satiety, reduces appetite, induces thermogenesis, increases energy expenditure, and reduces fat accumulation by inhibiting the reuptake of monoamine signaling factors such as 5-HT and norepinephrine by cells. Used for the treatment of obesity that cannot be reduced through diet control, exercise, and weight control.
Pharmacological action
Sibutramine is a non amphetamine type appetite suppressant and also has antidepressant properties. Sibutramine mainly acts through its secondary (M1) and primary (M2) amine metabolites, and its mechanism of action is to inhibit the reuptake of norepinephrine, serotonin, and dopamine, increase satiety, and accelerate energy expenditure, while having no significant effect on the release of norepinephrine, serotonin, and dopamine. The study also showed that sibutramine and its amine active metabolites have no significant anticholinergic, antihistamine, or monoamine oxidase inhibitory effects [6].