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l-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutane- methanamine has the structure represented by formula (I), is a inhibitor of 5- hydroxytryptamine and noradrenaline reuptake in vivo (neuropharmacology,28,pl29- 134), is useful in the treatment of depression, Parkinson's disease, obesity, insulin- independent diabetes mellirus, epilepsy, and the like. In addition, Sibutramine reduces body weight gain by dual action to reduce food intake by enhancing satiety and to increase energy expenditure by stimulating heat generation.

Sibutramine Maleate Sibutramine Fumarate

In accordance with one preferred aspect of the present invention, there is provided anhydrous crystalline Sibutramine Maleate with a moisture content of 0-1% characterized by Thermo gravimetric analysis (TGA) and KF method.

In accordance with another aspect of present invention, there is provided a crystalline Sibutramine Fumarate Form I as an anhydrate form with a moisture content of 0-0.3% characterized by Thermo gravimetric analysis (TGA) and KF method.

In accordance with the other aspect of present invention, there is provided a crystalline Sibutramine Fumarate Form II as a dihydrate with a moisture content of 9-11 % characterized by thermo gravimetric analysis (TGA) and KF method.

Furthermore, according to another aspect of present invention, there is provided an amorphous form of Sibutramine Fumarate characterized by powder X-ray diffraction pattern as shown in Figure 10. Brief Description of the Drawings

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Further objects of present invention together with additional features contributing thereto and advantages occurring there from will be apparent from the following description of preferred embodiments of the invention, which are shown in the accompanying drawings, wherein:

Figure 1 is the X-ray powder diffraction pattern of Sibutramine Maleate Figure 2 is the DSC of crystalline Sibutramine Maleate. Figure 3 is the TGA/DTA of crystalline Sibutramine Maleate. Figure 4 is the X-ray powder diffraction pattern of Sibutramine Fumarate Form I Figure 5 is the DSC of crystalline Sibutramine Fumarate Form I. Figure 6 is the TGA/DTA of crystalline Sibutramine Fumarate Form I. Figure 7 is the X-ray powder diffraction pattern of Sibutramine Fumarate Form II. Figure 8 is the DSC of crystalline Sibutramine Fumarate Form II. Figure 9 is the TGA of crystalline Sibutramine Fumarate Form II. Figure 10 is the X-ray powder diffraction pattern of amorphous Sibutramine Fumarate

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